Oral Diabetic Meds Unraveled

August 11, 2008 by  
Filed under DIABETES

1 Star2 Stars3 Stars4 Stars5 Stars (1 votes, average: 5.00 out of 5)

  • Pharmacology for diabetics has come a long way. Here’s a quick primer on the oral prescription products that are available. Note that Type II diabetics are prescribed oral medications as these agents are for people who don’t make enough insulin or are in most cases insulin resistant. The categories are described in layman’s terms and this is not an inclusive list. For more indepth information including adverse drug issues see the resources.

Classifications of Oral Agents:

Alpha-glucosidase Inhibitors:This type of drug delays the absorption of carbohydrates. They are generally taken with meals.

  • Miglitol (Glyset)
  • Acarbose (Precose)

Biguanides:Biguanides make the cells more sensitive to insulin and reduce plasma glucose levels.

  • Metformin (Glucophage, Glucophage XR, Glumetza, Fortamet, Riomet )

Dipeptidyl peptidase IV Inhibitors: The DPP-4 inhibitors increase insulin secretion and decrease gastric emptying.

  • Sitagliptin (Januvia)

Meglitinides:These drugs also increase the production of insulin in the pancreas. They are fast acting and usually given after meals

  • Repaglinide (Prandin)
  • Nateglinide (Starlix)

Thiazolidinediones: These drugs reverse insulin resistance.

  • Pioglitazone (Actos)
  • Rosiglitazone (Avandia)

Sulfonylureas: These drugs act on the pancreas to increase the production of insulin. They are not used for patients who have zero insulin production.

  • Glimepiride (Amyrl)
  • Glipizide (Glucotrol, Glucotrol XL)
  • Glyburide (Micronase, Diabeta, Aventis)

Combination Therapies:

  • ACTOplus met = Actos + Metformin
  • Avandaryl= Avandia + Glimiperide
  • Avandamet = rosiglitazone maleate + metformin
  • Duetact= Actos + glimepiride
  • Janumet= Januvia + metformin


Other Diabetes Medications-American Diabetes Association

Diabetes Medications-Islets of Hope

Diabetes Drugs-Consumer Reports (also features price comparisons)

Diabetes treatment: Medications for type 2 diabetes-Mayo Clinic


U.S. News & World Report, July 3, 2008. FDA Panel Calls for More Testing of Diabetes Drugs. Per the FDA, drugs designed to control type 2 diabetes should be subjected to more thorough safety reviews to ensure they don’t raise the risk of heart problems.

Science Daily, October 2, 2007. Clinical Trials For Diabetes Drugs Should Measure Outcomes Important To Patients, Doctors Urge. “Most clinical trials for new diabetes drugs do not consider the impact medication will have on a patient’s quality of life or other outcomes that are important to patients, such as the risk of developing complications associated with diabetes, according to a Mayo Clinic commentary in The Lancet.”

FoxNews . Com, May 22, 2007. Avandia: Getting the Facts. Fox News examines the findings of a study in the New England Journal of Medicine and the Avandia heart attack risk.

Related Posts with Thumbnails
Print Friendly, PDF & Email
  • Winsor Pilates


2 Responses to “Oral Diabetic Meds Unraveled”
  1. You know what I write these articles based on my ignorance.
    I have a day job at a pharmacy..but I don’t handle meds..I put in orders. And I realized how many new diabetic meds there are that I am clueless about. This really helped me to sort it out.
    Thanks for stopping by and posting Mike.

  2. Mike Nichols says:

    I’ve never seen the diabetic drugs outlined like this. Very interesting to see what types of drugs I’m taking. Great article!

Speak Your Mind

Tell us what you're thinking...
and oh, if you want a pic to show with your comment, go get a gravatar!


Random Battling For Health Products From Our Store

NOTE: The contents in this blog are for informational purposes only, and should not be construed as medical advice, diagnosis, treatment or a substitute for professional care. Always seek the advice of your physician or other qualified health professional before making changes to any existing treatment or program. Some of the information presented in this blog may already be out of date.

Read previous post:
B Cells Can Act Independent of T Cells In Autoimmune Diseases

In autoimmune diseases, it has long been believed by scientists that B cells (the source of damaging autoantibodies) are activated...