Long Break and New Insights on OA Inflammation

November 2, 2007 by  
Filed under ARTHRITIS

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Here in th Philippines, the National holidays seem to go on ’till this weekend.

First, we had local elections on 29th October, then 1st and 2nd November are All Saints’ and All Souls’ days, respectively. The later are two special days for visiting our dead loved ones in their resting places, which most often than not turns into some sort of family reunions.

Lucky employees are able to get a long vacation from work in order to go home to their families even far away in the provinces. Everyone else will be rushing back to work on Monday, some as early as Sunday to get a day’s rest before going back to their respective offices.

Times like such is bad for someone like me working at home. They all definitely get into my online routines, and once they’re all gone I have difficulty going to back to scheduled routine. But then the exercise of a long break is my chance to have long talks with people in person. (as if i don’t get enough of those while working at home?!)

Anyways (while I’m at it) let me pick on the most common degenerative joint disease : osteoarthritis (OA).

Articular cartilage is the type of cartilage that lines the ends of most limb bones – when this breaks down, osteoarthritis (OA) happens — when osteoarthritis later progresses, it will lead to inflammation around the affected joints of the sufferers.

The said inflammation has previously been attributed to bits of cartilage breaking off and aggravating the synovium (the thin, smooth membrane lining a joint). But now, new research is suggesting that other joint structures may be involved in triggering this inflammation.

Yet, MRI detection of prominent synovitis in early OA–when joint cartilage appears normal–suggests that other joint structures may be involved in triggering this inflammation.

Recent studies of inflammation in spinal arthritis implicate the enthesis, which is the attachment site of ligament or tendon to bone as being a potential driving factor in joint inflammation.

Intrigued by the potential role of tendon or ligament attachment sites in synovitis, Professors Michael Benjamin of Cardiff University and Dennis McGonagle of the University of Leeds decided to investigate the extent to which different entheses could contribute to inflammation by forming a functional unit and destructive partnership with adjacent synovium.

Findings of the said investigation were featured in Arthritis & Rheumatism, shedding light on a potential novel mechanism for synovial inflammation in degenerative arthritis.

Find more details from Science Daily and the article abstract.

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