Protein Test Could Spot Multiple Sclerosis Early

March 13, 2006 by  
Filed under MULTIPLE SCLEROSIS

1 Star2 Stars3 Stars4 Stars5 Stars (No Ratings Yet)
Loading...


03.09.06, 12:00 AM ET

THURSDAY, March 9 (HealthDay News) — A spinal fluid protein may prove useful in identifying people with the earliest stages of multiple sclerosis (MS), say researchers at Johns Hopkins University in Baltimore.

Currently, MS cannot be diagnosed with a simple blood sample or any other type of test.

“There is the possibility now that the protein we identified, 12.5 kDa cystatin, can be used to diagnose MS, perhaps in its earliest stages, and also to monitor treatment by measuring its levels in cerebrospinal fluid,” study author Dr. Avindra Nath, a professor in the department of neurology at Johns Hopkins University School of Medicine, said in a prepared statement.

She and her colleagues analyzed samples of cerebrospinal fluid from 29 people with MS or pre-MS symptoms, and found 12.5 kDa present in about two-thirds of the patients.

The Hopkins scientists showed that 12.5 kDa is a breakdown product of a larger protein called cystatin C, which blocks the activity of some enzymes, including cathepsin B. This enzyme has been linked to the demyelination — nerve sheath destruction — that occurs in people with MS.

About 10,000 Americans, mostly women, are diagnosed with MS each year. The disease causes muscle weakness, numbness, loss of muscle coordination, and problems with speech, vision and bladder control. In people with MS, the immune system destroys myelin, the covering of the nerves that helps transmit signals.

More information

The American Medical Association has more about MS.

Source

© Forbes.com Inc.™ All Rights Reserved

Related Posts with Thumbnails
Print Friendly, PDF & Email
  • Winsor Pilates

Speak Your Mind

Tell us what you're thinking...
and oh, if you want a pic to show with your comment, go get a gravatar!

*



Random Battling For Health Products From Our Store

NOTE: The contents in this blog are for informational purposes only, and should not be construed as medical advice, diagnosis, treatment or a substitute for professional care. Always seek the advice of your physician or other qualified health professional before making changes to any existing treatment or program. Some of the information presented in this blog may already be out of date.

Read previous post:
Multiple sclerosis drug to return with caveats

By Associated Press March 10, 2006 WASHINGTON - A multiple sclerosis drug pulled from the market a year ago because...

Close