Beauty Mantra – Cause for Dandruff and Remedies – Mind Body Soul

October 12, 2011 by  
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I just found this health related video on YouTube … and thought you might enjoy it!

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Beauty Mantra – Cause for Dandruff and Remedies – Mind Body Soul. Hair is a woman’s pride if she carries it well, but presence of dandruff can get really embarrassing. In this episode Divya deals with the topic of dandruff problem. Dr. Prachi Patil throws light on the fact that the cause of dandruff can be stressful lifestyle, faulty eating habits or use of chemical infused products. Care World’s ‘Beauty Mantra’ is a show for every woman who wants to look beautiful by enhancing her looks by way of home remedies rather than opting for temporary cosmetic solutions. The host, Dr. Divya Mangal, takes the audiences through the pros of using home remedies for solving skin and hair problems and the cons of using cosmetic products that may lead to various problems in the long term. Worth a dekko for women who believe in staying beautiful, the natural way! Log on to www.rajshri.com watch more beauty, health & Yoga tips.Log on to www.rajshri.com watch more beauty, health & Yoga tips.

Tell us what you think about this video in the comments below, or in the Battling For Health Community Forum!

Beauty Mantra – The Indian Sindoor & Bindi – Mind Body Soul

October 10, 2011 by  
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Beauty Mantra – The Indian Sindoor & Bindi – Mind Body Soul. Dr. Sumita Prajapati, the expert in this episode of ‘Beauty Mantra’, speaks about how to save oneself from the side effects of sindoor, which consists of chemicals that can harm the skin and hair. As an alternative, Dr. Sumitra suggests using natural products like Kumkum, Ashtaganda, Raktachandan. She points out to the side effects of using sticker bindis and also suggests treatment for the same. Care World’s ‘Beauty Mantra’ is a show for every woman who wants to look beautiful by enhancing her looks by way of home remedies rather than opting for temporary cosmetic solutions. The host, Dr. Divya Mangal, takes the audiences through the pros of using home remedies for solving skin and hair problems and the cons of using cosmetic products that may lead to various problems in the long term. Worth a dekko for women who believe in staying beautiful, the natural way! Log on to www.rajshri.com watch more beauty, health & Yoga tips.Log on to www.rajshri.com watch more beauty, health & Yoga tips.

Tell us what you think about this video in the comments below, or in the Battling For Health Community Forum!

Beauty Mantra – How to Get Glowing Shiny Skin – Mind Body Soul

October 7, 2011 by  
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Beauty Mantra – How to Get Glowing Shiny Skin – Mind Body Soul. In this episode of ‘Beauty Mantra’ Divya talks about microderma abrasion, an exfoliating technique that gives a fine and polished look to the skin. She tells in detail how skin is given that shining glow. Care World’s ‘Beauty Mantra’ is a show for every woman who wants to look beautiful by enhancing her looks by way of home remedies rather than opting for temporary cosmetic solutions. The host, Dr. Divya Mangal, takes the audiences through the pros of using home remedies for solving skin and hair problems and the cons of using cosmetic products that may lead to various problems in the long term. Worth a dekko for women who believe in staying beautiful, the natural way! Log on to www.rajshri.com watch more beauty, health & Yoga tips.Log on to www.rajshri.com watch more beauty, health & Yoga tips.

Tell us what you think about this video in the comments below, or in the Battling For Health Community Forum!

Beauty Mantra – Natural Tips on Hair Care – Mind Body Soul

October 5, 2011 by  
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Beauty Mantra – Natural Tips on Hair Care – Mind Body Soul. Many hair products contain chemicals that can cause hair to harden and become dull. Watch expert Dr.Sumita Prajapati offering natural tips on hair care.Care World Channel’s ‘Beauty Mantra’ is a show for every woman who wants to look beautiful by enhancing her looks by way of home remedies rather than opting for temporary cosmetic solutions. The host, Dr. Divya Mangal, takes the audiences through the pros of using home remedies for solving skin and hair problems and the cons of using cosmetic products that may lead to various problems in the long term. Worth a dekko for women who believe in staying beautiful, the natural way! Log on to www.rajshri.com to watch more beauty, health & Yoga tips.

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Beauty Mantra – Ayurveda for Permanant Glow – Mind Body Soul

September 21, 2011 by  
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Beauty Mantra – Ayurveda for Permanant Glow – Mind Body Soul. Expert Dr. Sumita Prajapati talks about instant glow techniques in this episode of ‘Beauty Mantra’. She is of the opinion that outer beauty is a reflection of inner health. Ayurveda can definitely help enhance outer looks. For a permanent instant glow, taking care of one’s inner health by eating the right food is of utmost importance. Care World’s ‘Beauty Mantra’ is a show for every woman who wants to look beautiful by enhancing her looks by way of home remedies rather than opting for temporary cosmetic solutions. The host, Dr. Divya Mangal, takes the audiences through the pros of using home remedies for solving skin and hair problems and the cons of using cosmetic products that may lead to various problems in the long term. Worth a dekko for women who believe in staying beautiful, the natural way! Log on to www.rajshri.com watch more beauty, health & Yoga tips.Log on to www.rajshri.com watch more beauty, health & Yoga tips.

Tell us what you think about this video in the comments below, or in the Battling For Health Community Forum!

Beauty Mantra – How to get Naturally Shiny & Healthy Hair – Mind Body Soul

September 16, 2011 by  
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I just found this health related video on YouTube … and thought you might enjoy it!

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Beauty Mantra – How to get Naturally Shiny & Healthy Hair – Mind Body Soul. A person who uses hair color more than once in a month is prone to bladder cancer! Divya thus deals with the topic of hair colors and hair dyes along with their probable side effects, method of application and various precautions while using hair color. Expert suggests some natural ingredients to acquire healthy and shining tresses. Care World Channel’s ‘Beauty Mantra’ is a show for every woman who wants to look beautiful by enhancing her looks by way of home remedies rather than opting for temporary cosmetic solutions. The host, Dr. Divya Mangal, takes the audiences through the pros of using home remedies for solving skin and hair problems and the cons of using cosmetic products that may lead to various problems in the long term. Worth a dekko for women who believe in staying beautiful, the natural way! Log on to www.rajshri.com watch more beauty, health & Yoga tips.Log on to www.rajshri.com watch more beauty, health & Yoga tips.

Tell us what you think about this video in the comments below, or in the Battling For Health Community Forum!

Beauty Mantra – Micro Derma – Latest Skin Polishing Technique – Health & Beauty Tips

September 4, 2011 by  
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I just found this health related video on YouTube … and thought you might enjoy it!

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Beauty Mantra – Micro Derma – Latest Skin Polishing Technique – Health & Beauty Tips. Micro Derma (a technique of skin polishing) is discussed by beauty expert Dr.Sumita Prajapati and host Dr. Divya as they talk about how this latest technique gives the skin a natural glow without using chemicals. Care World Channel’s ‘Beauty Mantra’ is a show for every woman who wants to look beautiful by enhancing her looks by way of home remedies rather than opting for temporary cosmetic solutions. The host, Dr. Divya Mangal, takes the audiences through the pros of using home remedies for solving skin and hair problems and the cons of using cosmetic products that may lead to various problems in the long term. Worth a dekko for women who believe in staying beautiful, the natural way! Log on to www.rajshri.com to watch more beauty, health & Yoga tips.

Tell us what you think about this video in the comments below, or in the Battling For Health Community Forum!

Beauty Mantra – Home Remedies to Reduce Pigmentation – Health & Beauty Tips

August 27, 2011 by  
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Beauty Mantra – Home Remedies to Reduce Pigmentation – Health & Beauty Tips. Fair and flawless skin is desired by everyone. But few attain it, that too, mostly by using chemical products. Beauty expert Dr. Sumita Prajapati talks about the problem of pigmentation and suggest easy home remedies to reduce pigmentation and help in skin whitening. Care World Channel’s ‘Beauty Mantra’ is a show for every woman who wants to look beautiful by enhancing her looks by way of home remedies rather than opting for temporary cosmetic solutions. The host, Dr. Divya Mangal, takes the audiences through the pros of using home remedies for solving skin and hair problems and the cons of using cosmetic products that may lead to various problems in the long term. Worth a dekko for women who believe in staying beautiful, the natural way! Log on to www.rajshri.com to watch more beauty, health & Yoga tips.

Tell us what you think about this video in the comments below, or in the Battling For Health Community Forum!

Beauty Mantra – Tips for making your Eyes look Appealing – Health & Beauty Tips

August 26, 2011 by  
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I just found this health related video on YouTube … and thought you might enjoy it!

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Beauty Mantra – Tips for making your Eyes look Appealing – Health & Beauty Tips. Dr. Divya and Dr. Sumita Prajapati, in this episode of ‘Beauty Mantra’, talk about the ways one can enhance the beauty of the eyes and make them look more attractive and appealing, naturally. They also answer viewer’s queries. Watch out for this informative episode.Care World Channel’s ‘Beauty Mantra’ is a show for every woman who wants to look beautiful by enhancing her looks by way of home remedies rather than opting for temporary cosmetic solutions. The host, Dr. Divya Mangal, takes the audiences through the pros of using home remedies for solving skin and hair problems and the cons of using cosmetic products that may lead to various problems in the long term. Worth a dekko for women who believe in staying beautiful, the natural way! Log on to www.rajshri.com to watch more beauty, health & Yoga tips.

Tell us what you think about this video in the comments below, or in the Battling For Health Community Forum!

Beauty Mantra – How to use Face Packs, Peels & Scrub – Health & Beauty Tips

August 2, 2011 by  
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I just found this health related video on YouTube … and thought you might enjoy it!

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Beauty Mantra – How to use Face Packs, Peels & Scrub – Health & Beauty Tips. A girl’s beautiful face adds to her overall personality. Thus it is important for her to know how to use products related to enhancing the beauty of her face. Host Divya and expert Dr. Prachi Patil speak about how to rightly select and apply face packs, peels and scrubs. Prachi tells about home-made masks for dry skin by mixing honey with milk. She also suggests ingredients for a face pack for oily skin. Care World’s ‘Beauty Mantra’ is a show for every woman who wants to look beautiful by enhancing her looks by way of home remedies rather than opting for temporary cosmetic solutions. The host, Dr. Divya Mangal, takes the audiences through the pros of using home remedies for solving skin and hair problems and the cons of using cosmetic products that may lead to various problems in the long term. Worth a dekko for women who believe in staying beautiful, the natural way! Log on to www.rajshri.com to watch more beauty, health & Yoga tips.

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Beauty Mantra – Healthy Natural Face Packs – Health & Beauty Tips

July 30, 2011 by  
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I just found this health related video on YouTube … and thought you might enjoy it!

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Beauty Mantra – Healthy Natural Face Packs – Health & Beauty Tips. Making natural face packs according to the skin type is important, as it will benefit more and lead to smooth and healthy skin. Beauty expert Dr. Sumita Prajapati talks about the easy-to-make and healthy natural face packs. Care World Channel’s ‘Beauty Mantra’ is a show for every woman who wants to look beautiful by enhancing her looks by way of home remedies rather than opting for temporary cosmetic solutions. The host, Dr. Divya Mangal, takes the audiences through the pros of using home remedies for solving skin and hair problems and the cons of using cosmetic products that may lead to various problems in the long term. Worth a dekko for women who believe in staying beautiful, the natural way! Log on to www.rajshri.com to watch more beauty, health & Yoga tips.

Tell us what you think about this video in the comments below, or in the Battling For Health Community Forum!

Beauty Mantra – Ways to Use Eye Cosmetics – Health & Beauty Tips

July 26, 2011 by  
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I just found this health related video on YouTube … and thought you might enjoy it!

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Beauty Mantra – Ways to Use Eye Cosmetics – Health & Beauty Tips. Eye products are one of the must-haves in every girl’s vanity bag. This episode deals with the side effects of eye cosmetics, how to remove eye make up in the right manner, how to check the expiry date of eye products and maintain the beauty of eyes in a natural manner. Care World Channel’s ‘Beauty Mantra’ is a show for every woman who wants to look beautiful by enhancing her looks by way of home remedies rather than opting for temporary cosmetic solutions. The host, Dr. Divya Mangal, takes the audiences through the pros of using home remedies for solving skin and hair problems and the cons of using cosmetic products that may lead to various problems in the long term. Worth a dekko for women who believe in staying beautiful, the natural way! Log on to www.rajshri.com watch more beauty, health & Yoga tips.Log on to www.rajshri.com to watch more beauty, health & Yoga tips.

Tell us what you think about this video in the comments below, or in the Battling For Health Community Forum!

Beauty Mantra – Home Remedies to get rid of Acne – Health & Beauty Tips

July 24, 2011 by  
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I just found this health related video on YouTube … and thought you might enjoy it!

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Beauty Mantra – Home Remedies to get rid of Acne – Health & Beauty Tips. Host Divya and Dr. Prachi Patil talk about acne and pimples in this informative episode of ‘Beauty Mantra’. They elaborate on the causes of acne – hormonal changes, infection or stressful lifestyle. They jot down the precautions one can take by using natural ingredients for cleaning and toning the skin. They also suggest various home-remedies to get rid of pimples. Care World’s ‘Beauty Mantra’ is a show for every woman who wants to look beautiful by enhancing her looks by way of home remedies rather than opting for temporary cosmetic solutions. The host, Dr. Divya Mangal, takes the audiences through the pros of using home remedies for solving skin and hair problems and the cons of using cosmetic products that may lead to various problems in the long term. Worth a dekko for women who believe in staying beautiful, the natural way! Log on to www.rajshri.com to watch more beauty, health & Yoga tips.

Tell us what you think about this video in the comments below, or in the Battling For Health Community Forum!

Side Effects of Synthetic Estrogen

May 5, 2011 by  
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I just found this health related video on YouTube … and thought you might enjoy it!

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www.iHealthTube.com Dr. Hyla Cass discourages young women from going on the birth control pill, saying it has dangerous side effect and there are other ways of dealing with PMS naturally. An educational video exclusive on iHealthTube. Twitter twitter.com Facebook: www.facebook.com Myspace: profile.myspace.com

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Childhood cancer effects track through adulthood

December 9, 2009 by  
Filed under CANCER

baby handFirst of all, we would like to extend our heartfelt condolences to the family of Noah Biorkman. I f you remember, we featured Noah on this site, a 5-year old boy who was suffering from stage IV neuroblastoma and whose utmost wish was to receive lots and lots of Christmas cards. Noah lost his battle with cancer on November 23. He received more than a million Christmas cards

****************

Continuing on the topic of neuroblastoma, children who survives is terrible cancer seem to carry the burden of the disease up to adulthood. The burden may not come in the recurrence of the cancer itself but neuroblastoma survivors are more likely to suffer from other chronic health conditions later in life than those who did not suffer from cancer, according to a study by American and Canadian researchers. In addition, their social life may also be badly affected.

The researchers looked at 954 neuroblastoma survivors as part of the Childhood Cancer Survivor Study (CCSS). These survivors were diagnosed with the disease from 1970 to 1986. The survivors were compared to a group of similar age who were siblings of children with cancer. The children were followed up for twenty years for recurrence of cancer and other health conditions.

The results showed that:

  • Neuroblastoma survivors are eight times more likely to suffer from chronic health conditions in adulthood, and these conditions include neurological, endocrine, sensory, and musculoskeletal complications.
  • The survivors are less likely to be married and less likely to be employed with high income compared to the sibling group.

According to study leader Caroline Laverdière, professor of pediatrics at the Université de Montréal and a researcher at the Sainte-Justine University Hospital Research Center

“Results of the current study underscore the need for close surveillance and life-long follow-up to improve potential medical and psychosocial effects of neuroblastoma. Future research should build on these findings and investigate risk factors for long-term complications of neuroblastoma treatment and second malignant tumour.”

About neuroblastoma

Neuroblastoma is a rare but deadly childhood cancer. It usually originates as a tumor in the sympathetic nervous system. The tumors are usually evident in the neck, chest, abdomen or pelvis but sometimes no primary tumor is visible.

According to the Children’s Neuroblastoma Cancer Foundation, about 600 to 700 cases of neuroblastoma are diagnosed each year. It is a pediatric cancer “that develops in young children-half of all cancers diagnosed in infants are neuroblastomas.  The median age at diagnosis is about 2 years old. Numerous children are diagnosed after age 2, but the number of diagnoses decreases as age increases.”

How subliminal words affect anti-obesity campaigns

May 4, 2009 by  
Filed under OBESITY

words-fitter_faster_strongerThe human brain is a complex biological machine that can sometimes act in ways unexpected in response to certain types of stimuli. Researchers have discovered, for example, that subliminal words (words that appeal to the subconscious) can trigger reactions opposite to what is actually desired.

Researchers from the University of Illinois investigated people’s subconscious responses to weight loss campaigns. It seems that when people read posters with messages that promote physical activity (e.g. take a walk, work out, etc.), the triggered reaction is – to eat more!

Study participants exposed to exercise messages ate about 20% more compared to peers exposed to other types of messages which have nothing to do with physical activity.

According to lead researcher Professor Dolores Albarracín

Those designing public health campaigns are in the habit of trying to change one behavior at a time…They should be aware that “whatever they communicate is likely to influence not only the behavior they had in mind but other behaviors that might be somewhat remotely linked,”

These findings are indeed very relevant in creating advertisements campaigns and public service announcement. The current strategy in fighting childhood obesity is curbing on advertisements of unhealthy food stuffs, which are to be replaced by messages encouraging healthy lifestyles that include good nutrition and physical exercise. It would be interesting to know whether the power of subliminal words have been taken into account in these messages.

In addition, it would also be important to know how other public campaign messages affect the target group’s behaviour. Some of the posters (aside from those against obesity) that I often see here in Europe are

  • campaigning for safe sex to fight AIDS
  • campaigning against drug addiction
  • campaigning against racism
  • campaigning against violence, child abuse
  • campaigning for the environment (e.g. global warming, overfishing, pollution, animal cruelty)
  • campaigning against world hunger

I really wonder whether these posters are getting their messages across.

So what goes in your mind when you see posters about weight loss and physical activity? Have you noticed how they affect your behavior?

Photo credit: stock.xchng

Drug Addiction and The Effects On Loved Ones

March 25, 2008 by  
Filed under ADDICTION

By Sandee Foxten

We were high school sweethearts. Reunited after nearly 20 years, he was the one my heart had always belonged to. Love at first site is real. That is how we fell in love. The first time we saw each other, our eyes met and from that moment on, my life has never been the same. My first marriage ended in divorce and my second marriage left me as a young widowed mother of two. About a year after my husband’s death, I got a very shocking email. He was looking for me! My high school sweetie was trying to find me and I just broke down and cried in disbelief. At the time, I thought it was fate. I was on top of the world thinking that I would finally be with that one special person I never seemed to be able to put out of my mind. After talking for awhile and getting up to date on each others lives, I learned that his life was far from joyous. At the time, he was in a place in another state that helps drug addicts. He had a job and seemed pretty stable. He told me he had been clean for two years. Not knowing anything about drugs myself, I thought that all he needed was me. I thought that as long as he had my love and knew it was true, he would never feel the need for drugs again. My entire world was fixing to be turned upside down.

After driving to another state to be reunited with my old flame, we decided that he would move to my city so we could be together. He found a job really quick, but couldn’t find a decent place to stay. So I allowed him to stay with me. That is a move that didn’t take me long to regret. Once he stayed and I was in his arms, I didn’t want to let go of him again. So my home became his home. It didn’t take long to learn that he hadn’t given up cocaine. He started staying out all night. The first time, it wasn’t just all night, he was gone for several days. The truth started becoming reality not long after that. We had went out to a bar with some friends and after a few drinks, he wanted me to take him to buy drugs. I refused and told him we were going home. On the way home, we got into a heated argument and he tried to hit me. I was driving and I pulled over on the side of the at 4am and told him to get out. I wasn’t sure who this man was, but it wasn’t somebody I loved. I felt bad and went back to pick him up. We agreed that he would leave that night. He was going to pack his clothes and I would take him to the bus station. But when we got home, he took off in one of my vehicles. After we cooled down and he got his drugs out of his system, we agreed to work it out. But things only got worse. On payday, he wouldn’t bother coming home. He was gone for the weekend, getting high. Eventually, he started stealing from me. He stole items from my home to trade for drugs or money to get drugs. He stole my credit cards and drained my bank accounts. I had to take leave from my job because the situation was so stressful.

“Baby Blue” as I call him, was honestly a good man when he was sober. Very caring, very loving and gentle. But once he started drinking and doing cocaine, he became very abusive and destructive. The situation progressively worsened. While on drugs, he would make up stuff and see things that I didn’t see. I knew it was the drugs. But he would accuse me of trying to hide things. Such as he thought I was cheating on him and that is the last thing I would do. Eventually, he took a trip back to his home state and never returned. The bad part, he stole one of my vehicles in the process. I had to drive to another state and hunt him down only to find he didn’t have my vehicle. He said he let someone drive it to the store and they never returned it. I will never forget the pain of that night. He was so strung out on drugs and I had him in my hotel room planning on having him arrested for the theft of my vehicle. It was this night that I found out what no woman would ever want to here. Never in a million years did I think one man could hurt me so much. He told me what he had been doing there those past few days and it was like someone shot a bullet right into my heart. He had been running around with a prostitute and had also been selling himself to other men for drugs. This man that I loved so much was sleeping with other men. I just wanted to die at that moment. I could not believe this was happening. What more could I do? What I did next was the hardest thing I had ever been through next to the death of my husband.

He wanted more drugs. He wanted me to take him. At first, I refused. Then after a few moments, I agreed. My intention was to find out where the drug dealer lived. I was from out of state, but I am very good at directions. I remembered the name of the road and number on the house. After returning to the hotel, he went in the bathroom and did his drug thing. That was the one that finally made him tired enough to sleep. I rubbed his back for him to ensure he would go to sleep. It was already after daybreak, so I made my move. I called the police. Within an hour, there were three police cars outside the hotel room door. I talked to them outside. They entered the room and woke him up. After asking a few questions, they decided to arrest him. He started fighting with them and I thought they were going to break his neck when they through him down on the bed. I was standing beside the wall and I just fell down on my knees begging him not to fight. As they took him away, the cops came back in to comfort me and told me to go home and to never come back. That boy was no good for me and I needed to stay away from him.

I cried all the way home, a four hour drive. I never returned to my job because the stress caused a back injury to worsen. “Baby Blue” spent four months in a detention center for theft of my vehicle. Today, he is back out on the streets and still doing drugs. I do not know what I could have done to save him. I think he is content doing what he does. As for me, my kids were far more important than having a man to love and run after. No man will ever come before my kids. My experiences have lead me to start a blog about drug and alcohol abuse. I have received great reviews for my work on this blog.

Please take time to visit at livedrugfree.blogspot.com

Article Source: EzineArticles.com/?expert=Sandee_Foxten

The Effects of Stress

October 13, 2007 by  
Filed under STRESS

Though some of the effects of stress are still hotly debated within the medical and psychological communities, there are some that are broadly agreed on. Rapid heartbeat, raised blood pressure, a rise in blood sugar level and a lower digestive rate are just a few of the physiological effects of stress.

The psychological effects, though sometimes more subtle, are important too. Increased stress, especially when it lasts over time, often leads to irritability. A person will be more quick-tempered and easy to anger. He or she will be more impatient, and more inclined to fear the future while feeling less able to cope with the present. People who are stressed tend to find it harder to concentrate and have greater difficulty making decisions.

These two realms are not unrelated. The hypothalamus and the pituitary gland are two brain components that lead the charge during stressful events. They release a substance called ACTH (adrenocorticotropic hormone) that stimulates the adrenal gland, near the kidney, to release cortisol. Natural levels of cortisol rise and fall during the day, but an excess can contribute to the “flight or fight” response that we experience during stress.

That can lead to neck muscle tension, stomach and bowel upset and a host of other effects. There are studies that suggest that if the stressful state persists it can lead to weakening of the immune system. That contributes to more frequent colds and other bad health effects.

High stress can cause a shortened attention span, less efficient memory recall, lowered objectivity and other cognitive problems. As dire thoughts race around the mind, there is less focus on solving life’s daily challenges in rational way. Moodiness, unreasonable anger, unwarranted feelings of injustice and other emotional consequences often follow.

The results of this are too often depression, apathy, crying in the absence of a specific cause, increased fear of failure and an overall sense of doom. But those are extremes and they are by no means inevitable.

There is sometimes a vicious cycle set up. The conflict between “I must” and “I can’t,” which is an essential element in stress, can lead to greater likelihood that, indeed, one can’t. That loss of confidence in one’s efficacy in dealing with life’s challenges can become a self-fulfilling prophecy. But that too is not inevitable.

By focusing on the factors that led to stress, evaluating them realistically and keeping a sense of perspective about their consequences, stress can be reduced and even eliminated before it becomes a chronic problem. That, in turn, helps reduce the occasions when a minor problem leads to major stress, even in the short term.

Multiple Sclerosis Drug Combined with Lipitor May Stop or Reverse Disease – Dosages Cut in Half with Fewer Negative Side Effects

March 22, 2006 by  
Filed under MULTIPLE SCLEROSIS

March 16th 2006

Combining treatments may improve outcomes for patients with Multiple Sclerosis (MS), according to research done on mice and published online by the Journal of Clinical Investigation. Scott S. Zamvil and colleagues at the University of California, San Francisco found that mice treated with a combination of Glatiramer acetate (GA) and atorvastatin (Lipitor) demonstrated “a significant prevention and reversal of clinical MS severity” of MS symptoms.

Lipitor is a cholesterol lowering drug that has previously been shown to improve MS symptoms. Glatiramer acetate (Teva Pharmaceutical Industries Ltd.’s Copaxone) is a drug currently approved for MS treatment. The researchers found that treating MS with combinations of immune modulating drugs can greatly reduce MS disease.

According to the researchers, treating EAE (experimental autoimmune encephalomyelitis) mice with the combination therapy caused the animals to lose less myelin, prevented CNS inflammation, and MS disease incidence.

The researchers then treated isolated inflammatory cells called macrophages with these drugs and found that the combination therapy mediated its effects by promoting the secretion of the anti-inflammatory molecule IL-10 and suppressed production of the proinflammatory molecules IL-12 and TNF-alpha.

The researchers believe that the combined delivery of drugs, which act through different mechanisms, may enhance the therapeutic efficacy of MS and reduce the negative side effects. Also the drug dosages were less than the dosages used in regular single drug treatments.

Copaxone has been shown to be 30 to 35 percent effective alone. According to Bloomberg News, all MS drugs have to be injected, and have “severe side effects”. None of the MS drugs are very potent.

Lipitor on the other hand can be taken orally and is considered relatively safe. Lipitor, the best selling drug in the world, appears to block production of immune system agents, called cytokines, involved in the disease process. Currently the University of California, San Francisco is looking for 152 patients at 14 hospitals to participate in clinical trials. These trials will investigate the effect Lipitor alone has on MS. Contact the office of Scott Zamvil, associate professor of neurology at University of California, San Francisco, for more information.

There are 400,000 MS sufferers in the US. The illness causes neurological symptoms that include loss of motor control, blindness and temporary recurring paralysis. The condition occur when the body’s natural defenses are over stimulated and begin stripping the protective insulation, called myelin, from nerve fibers in the central nervous system, which includes the brain, optic nerves and spinal cord.

Dan Wilson
Best Syndication

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Copyright 2005 Best Syndication
Last Updated Thursday, March 16, 2006 06:07 PM

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