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BRCA : Battling For Health

Cancer film feature: In the family

March 17, 2009 by  
Filed under CANCER

inthefamily_dvdHow much do you sacrifice to survive?

She was young, had a promising career as a filmmaker. Joanna Rudnick was 27 years old when she tested positive for a mutation in the breast cancer gene BRCA which makes her a high-risk candidate for breast and ovarian cancer. In a way, it seems inevitable because her family has a history of the diseases. In high risk cases like Joanna, pre-emptive removal of the said organs (prophylactic mastectomy and oophorectomy) is sometimes recommended before the monster cancer strikes.

Armed with a positive genetic test result that leaves her essentially ‘a ticking time bomb’, she balances dreams of having her own children with the unnerving reality that she is risking her life by holding on to her fertility. In The Family follows Joanna as she takes us on a journey through the unpredictable world of predictive genetic testing.

Turning the camera on herself, Joanna bares her conflicting emotions about preventative surgery and the potential consequences. Turning the camera on her new relationship, she and her partner capture a young couple falling in love in the shadow of the mutation. Turning the camera on the company that owns the patents to the BRCA genes, she questions their control over access to the test. Along the way, she looks to other women and families dealing with the same unbelievable information.”

Based on her experience, Joanna wrote, produced and directed “In the Family”. In the process of making the film, Rudnick tries to answer the question “How much do you sacrifice to survive?”

About the interventions

According to a research report at Columbia University, prophylactic mastectomy and oophorectomy can prolong life expectancy by about 8.5 years but “at a great cost to quality of life.” A more recent study University of Pennsylvania School of Medicine and Memorial Sloan-Kettering Cancer Center seems to confirm that ovary removal can substantially reduce the risk for both cancers.

The lifetime risk of breast cancer ranges from 56 percent to 84 percent, according to the researchers, whereas the risk for ovarian cancer ranges from 36 percent to 46 percent for BRCA1 mutation carriers and 10 percent to 27 percent for BRCA2 mutation carriers.

Cancer event at University of Michigan, March 17

On March 17, 2009, a forum at the University of Michigan will focus on community engagement and breast cancer research. The event at will kick off with a showing of “In the family” as part of the National Institutes of Health-funded program “Engaging the Community in Clinical Research.” The film showing will be followed by a panel discussion, including Joanna Rudnick herself.

Women’s Resource Fair Film Screening, March 20

The film will also be shown at The 2009 Evanston Women’s Resource Fair in Evanston, IL on March 20, 2009.

BRCA Mutations Not So Bad After All?

January 4, 2008 by  
Filed under CANCER

Yesterday, my friend Carey wrote a little bit about her family’s experience with BRCA genetic testing. Recently, I read a related article over at Ramunus’ excellent Cancer Genetics blog entitled, “When Having BRCA Mutation is Not So Bad or Even Better.”

It’s a pretty good brief explanation of two new studies that challenge the conventional thinking of BCRA mutation = bad. Check it out!

Living in a High-Risk Cancer Family

January 3, 2008 by  
Filed under CANCER

Because so many of members of my extended family have been diagnosed with cancer, I have always been keenly aware that I may have a stronger genetic predisposition for cancer than other individuals.

Growing up, my parents always stressed the importance of being vigilant when it came to proper screenings and making smart lifestyle choices that could help decrease my risk of major diseases.  One of my best friends, Carey Grayson, understood what I was going through.  In recent years, she’s had a staggering number of family members undergo their own battles with cancer.  Recently, I asked her to comment on her own thoughts about being in a high-risk cancer family.  Below is her reply:

There are so many questions that people have about cancer. The problem is that it never occurs to anyone to ask them until their lives are touched somehow by the disease. I know because I have been there six times now. Read more

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NOTE: The contents in this blog are for informational purposes only, and should not be construed as medical advice, diagnosis, treatment or a substitute for professional care. Always seek the advice of your physician or other qualified health professional before making changes to any existing treatment or program. Some of the information presented in this blog may already be out of date.