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First published in 1986 under the editorial direction of Dr. Henry J.M. Barnett, this encyclopedic, yet readable text has served as a one-stop shop for generations of practitioners seeking authoritative coverage of the scientific and clinical aspects of stroke. The 4th Edition features a new editorial team led by former co-editor Dr. J.P. Mohr, offering updated and expanded coverage of epidemiology and prevention, clinical manifestations, diagnosis, specific medical diseases related to stroke, pathophysiology, and medical and surgical therapy. Explains the mechanisms of stroke and stroke-related diseases. Provides comprehensive clinical guidance-from recognizing the clinical manifestations of stroke and using the latest laboratory and imaging studies to arrive at a diagnosis to medical and surgical treatment planning. Features a new editorial team led by former co-editor Dr. J.P. Mohr. Devotes a new section to Epidemiology and Prevention, with chapters on distribution, risk factors and prevention, and outcomes. Offers fresh perspectives from new authors on the latest advances in imaging, addressing functional neuroimaging, fast MRI, and more. Includes an expanded Pathophysiology section, with new chapters on excitotoxicity, apoptosis, inflammation, intracellular signaling, recovery of function, and more. Contains a reorganized and expanded Therapy section, with separate subsections on medical therapies (including new anticoagulants and neuroprotection agents) and surgical therapies (including new procedures for prevention and repair of stroke damage). With over 130 additional contributors.I. EPIDEMIOLOGY AND PREVENTION 1. Distribution of @vèõÂ?) ¾Û€